Datasets & Resources
Multi-omicsResearcherStudentClinician
- Human spaceflight data are protected health information. Most individual-level astronaut data need an approved research protocol and a formal request. ◆◆◆◆ High · E
- Omics and biology data from spaceflight, including Inspiration4, are in NASA's OSDR. Sensitive human data are behind controlled access. ◆◆◆◆ High · E
Proposed certainty (◆ High → ◇ Very low) and evidence-type tags: F flight · A analog · M model/animal · C computational · E expert/operational/standards. AI-proposed, pending reviewer confirmation. How to read the grades.
All links checked on 2026-10-14. Access rules change. Read each portal’s current terms before requesting data.
NASA Life Sciences Portal: LSDA and LSAH
- What: NASA’s gateway to human research data collected since 1961, including the Life Sciences Data Archive (LSDA) and the Lifetime Surveillance of Astronaut Health (LSAH) [1].
- Access: requests for human data need approval from an institutional review board (IRB) and NASA review. The process can take months [2].
- Links: NASA Life Sciences Portal · data request guidelines
NASA Open Science Data Repository (OSDR), including GeneLab
- What: NASA’s open repository for spaceflight biology and omics data [3][4]. OSDR expanded from the GeneLab omics database [6] in 2021, integrating the Ames Life Sciences Data Archive (ALSDA) [20]. GeneLab processes data with standardized pipelines [7]. Inspiration4 datasets are here [8].
- Access: most data are open. Sensitive human data are controlled-access and need a formal request [5].
- Links: OSDR repository · OSDR overview · requesting controlled-access data
ESA Human and Robotic Exploration Data Archive (HREDA)
- What: ESA’s archive of data from human and robotic exploration investigations back to 1972. It replaced the Erasmus Experiment Archive and was established in 2020 [9][10].
- Access: browsing is open. Downloading needs a sign-in [10].
- Links: HREDA · about HREDA · HREDA on ESA Cosmos
Space Omics and Medical Atlas (SOMA) portal
- What: interactive browsers for the SOMA and Inspiration4 data, from Weill Cornell Medicine [12][13][14]. SOMA increased public human space-omics data more than tenfold [16].
- Links: SOMA Browser · Inspiration4 multiome · Inspiration4 microbiome · Nature SOMA collection
NASA research records
- Human Research Roadmap: risks, gaps and tasks [17]. Risks list
- HRP evidence reports: NASA’s formal evidence reviews for each risk [18]. Evidence page
- NASA Task Book: project-level records of funded research [19]. Task Book
Tips
- Start with published, processed data (OSDR, SOMA browsers) before requesting individual-level human data.
- Plan months for LSDA requests, and include IRB approval in your timeline [2].
- Cite datasets by their accession IDs (for example, OSD numbers) as well as the paper.
Evidence profile
- Overall certainty
- ◆◆◆◆ High (proposed)
- Evidence types
- E · Expert / operational / standards
- Literature through
- 2026-10-14
Requirements referenced 0
No NASA-STD-3001 requirement maps directly to this page. See the standards quick reference.
References 20
- NASA Human Research Program. NASA Life Sciences Portal (NLSP). www.nasa.gov/hrp/nlsp/ NASA E
- NASA Life Sciences Portal. Data request guidelines. nlsp.nasa.gov/data-request-guidelines NASA E
- NASA Open Science Data Repository (OSDR): biological data repository. osdr.nasa.gov/bio/repo/ NASA E
- NASA. Open Science Data Repository (overview). www.nasa.gov/osdr/ NASA E
- NASA. OSDR tutorials: requesting controlled-access datasets. www.nasa.gov/reference/osdr-tutorials-requesting-controlled-… NASA E
- Berrios DC, et al. NASA GeneLab: interfaces for the exploration of space omics data. Nucleic Acids Res. 2021;49(D1):D1515–D1522. doi:10.1093/nar/gkaa887 PMID:33080015 Peer-reviewed E
- Overbey EG, et al. NASA GeneLab RNA-seq consensus pipeline: standardized processing of short-read RNA-seq data. iScience. 2021;24(4):102361. doi:10.1016/j.isci.2021.102361 PMID:33870146 Peer-reviewed E
- Sanders LM, et al. Inspiration4 data access through the NASA Open Science Data Repository. NPJ Microgravity. 2024;10:56. doi:10.1038/s41526-024-00393-5 PMID:38744887 Peer-reviewed E
- ESA. Human and Robotic Exploration Data Archive (HREDA). hreda.esac.esa.int/hreda/ Other E
- ESA. HREDA help: about. hreda.esac.esa.int/hreda-help/about/index.html Other E
- ESA Cosmos. HREDA. www.cosmos.esa.int/web/hreda Other E
- Weill Cornell Medicine. SOMA Browser. soma.weill.cornell.edu/apps/SOMA_Browser/ Other E
- Weill Cornell Medicine. Inspiration4 multiome browser. soma.weill.cornell.edu/apps/I4_Multiome/ Other E
- Weill Cornell Medicine. Inspiration4 microbiome browser. soma.weill.cornell.edu/apps/I4_Microbiome/ Other E
- Nature. The Space Omics and Medical Atlas (SOMA) collection. www.nature.com/collections/soma Other E
- Overbey EG, et al. The Space Omics and Medical Atlas (SOMA) and international astronaut biobank. Nature. 2024;632:1145–1154. doi:10.1038/s41586-024-07639-y PMID:38862028 Peer-reviewed F
- NASA Human Research Program. Human Research Roadmap: risks list. humanresearchroadmap.nasa.gov/risks/ NASA E
- NASA Human Research Program. Human Research Roadmap: evidence reports. humanresearchroadmap.nasa.gov/Evidence/ NASA E
- NASA Task Book (searchable record of funded HRP research). taskbook.nasaprs.com/ NASA E
- NASA Science. About OSDR. science.nasa.gov/biological-physical/data/osdr/ NASA E
Machine-checked on 2026-10-14: each URL resolved, each DOI's title/journal/year matched via Crossref, and claims were checked against the source text (abstract or full NASA page). Human verification against full text is still required before review. NASA documents are U.S. Government works (public domain) and are summarized with attribution; journal articles are summarized, not reproduced.
Article info
- Authors
- Pending (AI-assisted draft)
- Reviewer
- Pending review
- Last reviewed
- Pending review
- Literature through
- 2026-10-14
- AI-assisted
- Yes (disclosed)
- COI
- Pending
- License
- CC BY-SA 4.0
- Use
- Educational only · Disclaimer
- Cite this version
- Pending first edition